A Chinese family affected by lynch syndrome caused by MLH1 mutation

• Main Authors: Shuqin Jia (Author), Meng Zhang (Author), Yu Sun (Author), Hai Yan (Author), Fangping Zhao (Author), Ziyu Li (Author), Jiafu Ji (Author)
• Format: Book
• Published: BMC, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Lynch syndrome (LS) is caused by mutations in DNA mismatch repair (MMR) genes, which accounts for 3-5% of colorectal cancer. The risks of several types of cancer are greatly increased among individuals with LS. In this study, 4 members of a Chinese family with a MLH1 pathogenic v...