In Vitro Metabolism of DWP16001, a Novel Sodium-Glucose Cotransporter 2 Inhibitor, in Human and Animal Hepatocytes

• Main Authors: Ju-Hyun Kim (Author), Dong Kyun Kim (Author), Won-Gu Choi (Author), Hye-Young Ji (Author), Ji-Soo Choi (Author), Im-Sook Song (Author), Sangkyu Lee (Author), Hye Suk Lee (Author)
• Format: Book
• Published: MDPI AG, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DWP16001 is currently in a phase 2 clinical trial as a novel anti-diabetes drug for the treatment of type 2 diabetes by selective inhibition of sodium-glucose cotransporter 2. This in vitro study was performed to compare the metabolism of DWP16001 in human, dog, monkey, mouse, and rat hepatocytes, a...