In Vitro Metabolism of DWP16001, a Novel Sodium-Glucose Cotransporter 2 Inhibitor, in Human and Animal Hepatocytes

• Hoofdauteurs: Ju-Hyun Kim (Auteur), Dong Kyun Kim (Auteur), Won-Gu Choi (Auteur), Hye-Young Ji (Auteur), Ji-Soo Choi (Auteur), Im-Sook Song (Auteur), Sangkyu Lee (Auteur), Hye Suk Lee (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2020-09-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

DWP16001 is currently in a phase 2 clinical trial as a novel anti-diabetes drug for the treatment of type 2 diabetes by selective inhibition of sodium-glucose cotransporter 2. This in vitro study was performed to compare the metabolism of DWP16001 in human, dog, monkey, mouse, and rat hepatocytes, a...