Combining random mutagenesis, structure-guided design and next-generation sequencing to mitigate polyreactivity of an anti-IL-21R antibody
Despite substantial technological advances in antibody library and display platform development, the number of approved biotherapeutics from displayed libraries remains limited. In vivo, 20-50% of peripheral B cells undergo a process of receptor editing, which modifies the variable and junctional re...
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| Main Authors: | , , , , , , , , |
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| Format: | Book |
| Published: |
Taylor & Francis Group,
2021-01-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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