Molecular modeling of human APOBEC3G to predict the binding modes of the inhibitor compounds IMB26 and IMB35

• मुख्य लेखकों: Zhixin Zhang (लेखक), Congjie Zhai (लेखक), Zeyun Mi (लेखक), Jiwei Ding (लेखक), Yongxin Zhang (लेखक), Xing Shi (लेखक), Xiaoyu Li (लेखक), Liyan Yu (लेखक), Zhuorong Li (लेखक), Jiandong Jiang (लेखक), Jinming Zhou (लेखक), Shan Cen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2013-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

APOBEC3G(A3G) is a host cytidine deaminase that incorporates into HIV-1 virions and efficiently inhibits viral replication. The virally encoded protein Vif binds to A3G and induces its degradation, thereby counteracting the antiviral activity of A3G. Vif-mediated A3G degradation clearly represents a...