Molecular modeling of human APOBEC3G to predict the binding modes of the inhibitor compounds IMB26 and IMB35

• Main Authors: Zhixin Zhang (Author), Congjie Zhai (Author), Zeyun Mi (Author), Jiwei Ding (Author), Yongxin Zhang (Author), Xing Shi (Author), Xiaoyu Li (Author), Liyan Yu (Author), Zhuorong Li (Author), Jiandong Jiang (Author), Jinming Zhou (Author), Shan Cen (Author)
• Format: Book
• Published: Elsevier, 2013-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

APOBEC3G(A3G) is a host cytidine deaminase that incorporates into HIV-1 virions and efficiently inhibits viral replication. The virally encoded protein Vif binds to A3G and induces its degradation, thereby counteracting the antiviral activity of A3G. Vif-mediated A3G degradation clearly represents a...