Ascorbic acid has superior ex vivo antiproliferative, cell death-inducing and immunomodulatory effects over IFN-α in HTLV-1-associated myelopathy.

• Main Authors: Britta Moens (Author), Daniele Decanine (Author), Soraya Maria Menezes (Author), Ricardo Khouri (Author), Gilvanéia Silva-Santos (Author), Giovanni Lopez (Author), Carolina Alvarez (Author), Michael Talledo (Author), Eduardo Gotuzzo (Author), Ramon de Almeida Kruschewsky (Author), Bernardo Galvão-Castro (Author), Anne-Mieke Vandamme (Author), Johan Van Weyenbergh (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: Clear therapeutic guidelines for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) are missing due to the lack of randomized double-blind controlled clinical trials. Moderate yet similar clinical benefit has been demonstrated for IFN-α and high-dose ascorbic acid (AA) m...