Suppression of endothelial miR-22 mediates non-small cell lung cancer cell-induced angiogenesis

• Main Authors: Yuan Gu (Author), Gianni Pais (Author), Vivien Becker (Author), Christina Körbel (Author), Emmanuel Ampofo (Author), Elke Ebert (Author), Johannes Hohneck (Author), Nicole Ludwig (Author), Eckart Meese (Author), Rainer M. Bohle (Author), Yingjun Zhao (Author), Michael D. Menger (Author), Matthias W. Laschke (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNAs (miRNAs) expressed in endothelial cells (ECs) are powerful regulators of angiogenesis, which is essential for tumor growth and metastasis. Here, we demonstrated that miR-22 is preferentially and highly expressed in ECs, while its endothelial level is significantly downregulated in human no...