Pancreatic, but not myeloid-cell, expression of interleukin-1alpha is required for maintenance of insulin secretion and whole body glucose homeostasis

• Main Authors: J. Jason Collier (Author), Heidi M. Batdorf (Author), Thomas M. Martin (Author), Kristen E. Rohli (Author), David H. Burk (Author), Danhong Lu (Author), Chris R. Cooley (Author), Michael D. Karlstad (Author), Joseph W. Jackson (Author), Tim E. Sparer (Author), Jingying Zhang (Author), Randall L. Mynatt (Author), Susan J. Burke (Author)
• Format: Book
• Published: Elsevier, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: The expression of the interleukin-1 receptor type I (IL-1R) is enriched in pancreatic islet β-cells, signifying that ligands activating this pathway are important for the health and function of the insulin-secreting cell. Using isolated mouse, rat, and human islets, we identified the cyto...