Structure- and machine learning-guided engineering demonstrate that a non-canonical disulfide in an anti-PD-1 rabbit antibody does not impede antibody developability

• Κύριοι συγγραφείς: Wei-Ching Liang (Συγγραφέας), Hongkang Xi (Συγγραφέας), Dawei Sun (Συγγραφέας), Luigi D'Ascenzo (Συγγραφέας), Jonathan Zarzar (Συγγραφέας), Nicole Stephens (Συγγραφέας), Ryan Cook (Συγγραφέας), Yinyin Li (Συγγραφέας), Zhengmao Ye (Συγγραφέας), Marissa Matsumoto (Συγγραφέας), Jian Payandeh (Συγγραφέας), Matthieu Masureel (Συγγραφέας), Yan Wu (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

ABSTRACTRabbits produce robust antibody responses and have unique features in their antibody repertoire that make them an attractive alternative to rodents for in vivo discovery. However, the frequent occurrence of a non-canonical disulfide bond between complementarity-determining region (CDR) H1 (C...