Leptin deficiency mitigates cutaneous inflammation in a mouse model of psoriasis

• Main Authors: Xinyan SHE (Author), Min OU (Author), Yang LI (Author), Xiuqiu LIN (Author), Junjie LIN (Author), Kai XIE (Author), Xiaohua WANG (Author)
• Format: Book
• Published: editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective To explore the effect of leptin on inflammation in psoriasis-like skin induced by imiquimod (IMQ). Methods Eight leptin gene knockout (ob/ob) obese mice and eight normal control (wt) mice were randomly divided into four groups (n=4 each), i.e. wt-IMQ, wt-vaseline, ob/ob-IMQ, ob/ob-vaseline...