Naxitamab Activity in Neuroblastoma Cells Is Enhanced by Nanofenretinide and Nanospermidine

• Main Authors: Lucrezia Galassi (Author), Martina Rossi (Author), Pietro Lodeserto (Author), Monia Lenzi (Author), Francesca Borsetti (Author), Manuela Voltattorni (Author), Giovanna Farruggia (Author), Paolo Blasi (Author), Isabella Orienti (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neuroblastoma cells highly express the disialoganglioside GD2, a tumor-associated carbohydrate antigen, which is also expressed in neurons, skin melanocytes, and peripheral nerve fibers. Immunotherapy with monoclonal anti-GD2 antibodies has a proven efficacy in clinical trials and is included in the...