A novel cell-based screen identifies chemical entities that reverse the immune-escape phenotype of metastatic tumours

• Main Authors: Lilian L. Nohara (Author), Samantha L. S. Ellis (Author), Carola Dreier (Author), Sarah Dada (Author), Iryna Saranchova (Author), Kyong Bok Choi (Author), Lonna Munro (Author), Cheryl G. Pfeifer (Author), Eliana Al Haddad (Author), Krysta M. Coyle (Author), Jessica R. Morrice (Author), Daniel Joo Sung Shim (Author), Paul Ahn (Author), Nicole De Voogd (Author), David E. Williams (Author), Ping Cheng (Author), Emmanuel Garrovillas (Author), Raymond J. Andersen (Author), Wilfred A. Jefferies (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Genetic and epigenetic events have been implicated in the downregulation of the cellular antigen processing and presentation machinery (APM), which in turn, has been associated with cancer evasion of the immune system. When these essential components are lacking, cancers develop the ability to subve...