Small RNA-Mediated Epigenetic Myostatin Silencing

• Main Authors: Thomas C Roberts (Author), Samir EL Andaloussi (Author), Kevin V Morris (Author), Graham McClorey (Author), Matthew JA Wood (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Myostatin (Mstn) is a secreted growth factor that negatively regulates muscle mass and is therefore a potential pharmacological target for the treatment of muscle wasting disorders such as Duchenne muscular dystrophy. Here we describe a novel Mstn blockade approach in which small interfering RNAs (s...