An Approach to Evaluate the Effective Cytoplasmic Concentration of Bioactive Agents Interacting with a Selected Intracellular Target Protein

• Main Authors: Yuri V. Khramtsov (Author), Alexey V. Ulasov (Author), Andrey A. Rosenkranz (Author), Tatiana A. Slastnikova (Author), Tatiana N. Lupanova (Author), Georgii P. Georgiev (Author), Alexander S. Sobolev (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To compare the effectiveness of various bioactive agents reversibly acting within a cell on a target intracellular macromolecule, it is necessary to assess effective cytoplasmic concentrations of the delivered bioactive agents. In this work, based on a simple equilibrium model and the cellular therm...