Altered Pharmacokinetics of Daunorubicin in Rats with CCl4-Induced Hepatic Injury

• Main Authors: Min-Koo Choi (Author), Im-Sook Song (Author), Dae-Duk Kim (Author), Suk-Jae Chung (Author), Chang-Koo Shim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2007-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

PURPOSE. The effect of CCl4-induced experimental hepatic injury (CCl4-EHI) on the pharmacokinetics of daunorubicin was investigated systemically in rats, in an attempt to elucidate the major determinants of the effect of CCl4-EHI on the pharmacokinetics of the drug. METHODS. CCl4-EHI was induced in...