The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection.

• Main Authors: Duc Minh Nguyen (Author), Cristina Poveda (Author), Jeroen Pollet (Author), Fabian Gusovsky (Author), Maria Elena Bottazzi (Author), Peter J Hotez (Author), Kathryn Marie Jones (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Chagas disease, chronic infection with Trypanosoma cruzi, mainly manifests as cardiac disease. However, the liver is important for both controlling parasite burdens and metabolizing drugs. Notably, high doses of anti-parasitic drug benznidazole (BNZ) causes liver damag...