A high throughput method for Monitoring of Sorafenib, regorafenib, cabozantinib and their metabolites with UPLC-MS/MS in rat plasma

As multi-targeted tyrosine kinase inhibitors, sorafenib, regorafenib and cabozantinib are widely used in hepatocellular carcinoma (HCC) for systemic therapies with anti-proliferative and anti-angiogenic effects. Nevertheless, adverse effects or insufficient efficacy appear frequently due to the plas...

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Main Authors: Er-Min Gu (Author), Ya-Nan Liu (Author), Lvjun Pan (Author), Yingying Hu (Author), Xuemei Ye (Author), Pingping Luo (Author)
Format: Book
Published: Frontiers Media S.A., 2022-09-01T00:00:00Z.
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