Cover Image

A high throughput method for Monitoring of Sorafenib, regorafenib, cabozantinib and their metabolites with UPLC-MS/MS in rat plasma

As multi-targeted tyrosine kinase inhibitors, sorafenib, regorafenib and cabozantinib are widely used in hepatocellular carcinoma (HCC) for systemic therapies with anti-proliferative and anti-angiogenic effects. Nevertheless, adverse effects or insufficient efficacy appear frequently due to the plas...

Full description

Saved in:

Bibliographic Details
Main Authors:	Er-Min Gu (Author), Ya-Nan Liu (Author), Lvjun Pan (Author), Yingying Hu (Author), Xuemei Ye (Author), Pingping Luo (Author)
Format:	Book
Published:	Frontiers Media S.A., 2022-09-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Effect of Baicalein on the Pharmacokinetics of Cilostazol and Its Two Metabolites in Rat Plasma Using UPLC-MS/MS Method
by: Qinghua Weng, et al.
Published: (2022)

An Efficient UPLC-MS/MS Method Established to Detect Relugolix Concentration in Rat Plasma
by: Liying Xing, et al.
Published: (2022)

UPLC-MS/MS Technology for the Quantitative Methodology and Pharmacokinetic Analysis of Voxtalisib in Rat Plasma
by: Qingqing Li, et al.
Published: (2022)

Development of a UPLC-MS/MS method for the determination of orelabrutinib in rat plasma and its application in pharmacokinetics
by: Ya-nan Liu, et al.
Published: (2022)

Development and validation of a UPLC-MS/MS method for simultaneous detection of doxorubicin and sorafenib in plasma: Application to pharmacokinetic studies in rats
by: Alanoud Altalal, et al.
Published: (2023)

Method development and validation of cabozantinib by LC-MS/MS
by: Punna Venkateshwarlu, et al.
Published: (2022)

Development and validation of a high throughput UPLC-MS/MS method for simultaneous quantification of esomeprazole, rabeprazole and levosulpiride in human plasma
by: Raja Haranadha Babu Chunduri, et al.
Published: (2016)

A Novel UPLC-MS/MS Assay for the Measurement of Linezolid and its Metabolite PNU-142300 in Human Serum and its Application to Patients With Renal Insufficiency
by: Yingying Wang, et al.
Published: (2021)

A sensitive bioanalytical method development and validation of cabozantinib in human plasma by LC-ESI-MS/MS
by: Srikanth Inturi, et al.
Published: (2018)

Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study
by: Li S, et al.
Published: (2020)

Development and validation of UPLC-MS/MS method for icariin and its metabolites in mouse urine
by: Na Li, et al.
Published: (2024)

UPLC-MS/MS quantification of quercetin in plasma and urine following parenteral administration
by: Igor A. Zupanets, et al.
Published: (2019)

Establishment of a sensitive UPLC-MS/MS method to quantify safinamide in rat plasma
by: Ying Wang, et al.
Published: (2023)

Effects of Dexmedetomidine on the Pharmacokinetics of Dezocine, Midazolam and Its Metabolite 1-Hydroxymidazolam in Beagles by UPLC-MS/MS
by: Zhou W, et al.
Published: (2020)

Evaluation of herb-drug interaction of ambrisentan with shikonin based on UPLC-MS/MS
by: Tian Lan, et al.
Published: (2021)

Highly sensitive assay for the determination of therapeutic peptide desmopressin in human plasma by UPLC-MS/MS
by: Shiva Kumar Gudlawar, et al.
Published: (2017)

Determination of parecoxib and valdecoxib in rat plasma by UPLC-MS/MS and its application to pharmacokinetics studies
by: Mengchun Chen, et al.
Published: (2020)

Determination of lercanidipine in human plasma by an improved UPLC-MS/MS method for a bioequivalence study
by: Darshan V. Chaudhary, et al.
Published: (2016)

Qualitative and Quantitative Analysis of Phytochemicals in Sayeok-Tang via UPLC-Q-Orbitrap-MS and UPLC-TQ-MS/MS
by: Yu Jin Kim, et al.
Published: (2024)

Validated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study
by: Mei YB, et al.
Published: (2019)

Development of an UPLC-MS/MS Method for the Quantitative Analysis of Upadacitinib in Beagle Dog Plasma and Pharmacokinetics Study
by: Wang MJ, et al.
Published: (2021)

Effect of Sophocarpine on the Pharmacokinetics of Umbralisib in Rat Plasma Using a Novel UPLC-MS/MS Method
by: Qinghua Weng, et al.
Published: (2022)

UPLC-MS/MS for the determination of azilsartan in beagle dog plasma and its application in a pharmacokinetics study
by: Cheng Gong, et al.
Published: (2015)

Application of a UPLC-MS/MS method to the protein binding study of TM-2 in rat, human and beagle dog plasma
by: Hui Liu, et al.
Published: (2016)

UPLC-MS/MS method for Icariin and metabolites in whole blood of C57 mice: development, validation, and pharmacokinetics study
by: Wei Liu, et al.
Published: (2023)

Development of a UPLC-MS/MS method for the determination of lacosamide and its metabolite and its application to drug-drug interaction
by: Jie Chen, et al.
Published: (2023)

Evaluation of the inhibitory effect of quercetin on the pharmacokinetics of tucatinib in rats by a novel UPLC-MS/MS assay
by: Ying Zhang, et al.
Published: (2022)

UPLC-MS/MS assay for quantification of an inhibitor of kinases (Foretinib) in plasma: Application to a pharmacokinetic study in rats
by: Essam Ezzeldin, et al.
Published: (2020)

Development of a robust UPLC-MS/MS method for the quantification of riluzole in human plasma and its application in pharmacokinetics
by: Zhuo Sun, et al.
Published: (2023)

Simultaneous Determination of Celecoxib, Dezocine and Dexmedetomidine in Beagle Plasma Using UPLC-MS/MS Method and the Application in Pharmacokinetics
by: Hu J, et al.
Published: (2021)

Development and validation of a rapid, simple, and reliable UPLC-MS/MS method for the quantification of vancomycin in human plasma
by: Tho Do Chau Minh Vinh, et al.
Published: (2024)

Comparative Pharmacokinetics of Cinobufacini Capsule and Injection by UPLC-MS/MS
by: Ming Li, et al.
Published: (2022)

Pharmacokinetics, Bioavailability, and Tissue Distribution Study of Angoroside C and Its Metabolite Ferulic Acid in Rat Using UPLC-MS/MS
by: Chenning Zhang, et al.
Published: (2018)

Quantification of 6-Mercaptopurine and Its Metabolites in Patients with Acute Lympoblastic Leukemia Using Dried Blood Spots and UPLC-MS/MS
by: Supandi Supandi, et al.
Published: (2018)

Determination of asenapine in presence of its inactive metabolites in human plasma by LC-MS/MS
by: Nirav P. Patel, et al.
Published: (2018)

Simultaneous determination of indapamide, perindopril and perindoprilat in human plasma or whole blood by UPLC-MS/MS and its pharmacokinetic application
by: Yi Tao, et al.
Published: (2018)

Randomized double-blinded pilot clinical study of the antidiabetic activity of Balanites aegyptiaca and UPLC-ESI-MS/MS identification of its metabolites
by: Hend Rashad, et al.
Published: (2017)

Ultra-sensitive bioanalysis of the therapeutic peptide exenatide for accurate pharmacokinetic analyses at effective plasma concentrations utilizing UPLC-MS/MS
by: Max Sauter, et al.
Published: (2020)

Development and Validation a UPLC-MS/MS Method for Quantification of Pentoxifylline in Beagle Plasma: Application for Pharmacokinetic Study of Food Effect
by: Xu Y, et al.
Published: (2023)

UPLC-ESI/MS/MS Profiling and Anti-Inflammatory Activity of Gleditsia caspica
by: Hager Ashraf, et al.
Published: (2020)