MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α

• Main Authors: Li Xu (Author), Wen J. Sun (Author), Ai J. Jia (Author), Lu L. Qiu (Author), Bing Xiao (Author), Lin Mu (Author), Jian M. Li (Author), Xiu F. Zhang (Author), Yan Wei (Author), Cong Peng (Author), Dong S. Zhang (Author), Xu D. Xiang (Author)
• Format: Book
• Published: BMC, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background T helper 17 (Th17) cells have proven to be crucial in the pathogenesis of neutrophils-dominant asthma. Hypoxia inducible factor-1α (HIF-1α) is involved in allergic responses in asthma. Our previous studies indicated that Methtyl-CpG binding domain protein 2 (MBD2) expression was...