Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Treatment Resistance in Breast Cancer

Utility of a Novel Three-Dimensional and Dynamic (3DD) Cell Culture System for PK/PD Studies: Evaluation of a Triple Combination Therapy at Overcoming Anti-HER2 Treatment Resistance in Breast Cancer

Background: Emergence of Human epidermal growth factor receptor 2 (HER2) therapy resistance in HER2-positive (HER2+) breast cancer (BC) poses a major clinical challenge. Mechanisms of resistance include the over-activation of the PI3K/mTOR and Src pathways. This work aims to investigate a novel comb...

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Main Authors: Anusha Ande (Author), Tanaya R. Vaidya (Author), Bao N. Tran (Author), Michael Vicchiarelli (Author), Ashley N. Brown (Author), Sihem Ait-Oudhia (Author)
Format: Book
Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
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3rd Floor Main Library

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