Antibody CDR loops as ensembles in solution vs. canonical clusters from X-ray structures

• Hauptverfasser: Monica L. Fernández-Quintero (Verfasst von), Martin C. Heiss (Verfasst von), Nancy D. Pomarici (Verfasst von), Barbara A. Math (Verfasst von), Klaus R. Liedl (Verfasst von)
• Format: Buch
• Veröffentlicht: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

In the past decade, the relevance of antibodies as therapeutics has increased substantially. Therefore, structural and functional characterization, in particular of the complementarity-determining regions (CDRs), is crucial to the design and engineering of antibodies with unique binding properties....