Chronic administration of a leupeptin-derived calpain inhibitor fails to ameliorate severe muscle pathology in a canine model of Duchenne muscular dystrophy

• Main Authors: Martin K Childers (Author), Janet R Bogan (Author), Daniel J Bogan (Author), Hansel eGreiner (Author), Melanie eHolder (Author), Robert eGrange (Author), Joe N Kornegay (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calpains likely play a role in the pathogenesis of Duchenne muscular dystrophy (DMD). Accordingly, calpain inhibition may provide therapeutic benefit to DMD patients. In the present study, we sought to measure benefit from administration of a novel calpain inhibitor, C101, in a canine muscular dystr...