Mitochondrial DNA variants and microbiota: An experimental strategy to identify novel therapeutic potential in chronic inflammatory diseases

• Main Authors: Michael Olbrich (Author), Adina-Malin Hartmann (Author), Sven Künzel (Author), Zouhair Aherrahrou (Author), Paul Schilf (Author), John F. Baines (Author), Saleh M. Ibrahim (Author), Misa Hirose (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously demonstrated that mice carrying natural mtDNA variants of the FVB/NJ strain (m.7778 G>T in the mt-Atp8 gene in mitochondrial complex V), namely C57BL/6 J-mtFVB/NJ (B6-mtFVB), exhibited (i) partial protection from experimental skin inflammatory diseases in an anti-murine type VII col...