The Xanthine Oxidase Inhibitor Febuxostat Suppresses Adipogenesis and Activates Nrf2

• Main Authors: Yoshiki Higa (Author), Masahiro Hiasa (Author), Hirofumi Tenshin (Author), Emiko Nakaue (Author), Mariko Tanaka (Author), Sooha Kim (Author), Motosumi Nakagawa (Author), So Shimizu (Author), Kotaro Tanimoto (Author), Jumpei Teramachi (Author), Takeshi Harada (Author), Asuka Oda (Author), Masahiro Oura (Author), Kimiko Sogabe (Author), Tomoyo Hara (Author), Ryohei Sumitani (Author), Tomoko Maruhashi (Author), Hiroki Yamagami (Author), Itsuro Endo (Author), Toshio Matsumoto (Author), Eiji Tanaka (Author), Masahiro Abe (Author)
• Format: Book
• Published: MDPI AG, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Xanthine oxidoreductase (XOR) is a rate-limiting enzyme in purine catabolism that acts as a novel regulator of adipogenesis. In pathological states, xanthine oxidoreductase activity increases to produce excess reactive oxygen species (ROS). The nuclear factor erythroid 2-related factor 2 (Nrf2) is a...