In vitro and in vivo efficacy of ether lipid edelfosine against Leishmania spp. and SbV-resistant parasites.

• Main Authors: Rubén E Varela-M (Author), Janny A Villa-Pulgarin (Author), Edward Yepes (Author), Ingrid Müller (Author), Manuel Modolell (Author), Diana L Muñoz (Author), Sara M Robledo (Author), Carlos E Muskus (Author), Julio López-Abán (Author), Antonio Muro (Author), Iván D Vélez (Author), Faustino Mollinedo (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: The leishmaniases are a complex of neglected tropical diseases caused by more than 20 Leishmania parasite species, for which available therapeutic arsenal is scarce and unsatisfactory. Pentavalent antimonials (SbV) are currently the first-line pharmacologic therapy for leishmaniasis worl...