Apixaban and rivaroxaban's physiologically‐based pharmacokinetic model validation in hospitalized patients: A first step for larger use of a priori modeling approach at bed side

• Main Authors: Jean Terrier (Author), Frédéric Gaspar (Author), Pauline Gosselin (Author), Olivier Raboud (Author), Camille Lenoir (Author), Victoria Rollason (Author), Chantal Csajka (Author), Caroline Samer (Author), Pierre Fontana (Author), Youssef Daali (Author), Jean‐Luc Reny (Author), for the OptimAT study group (Author)
• Format: Book
• Published: Wiley, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract When used in real‐world conditions, substantial interindividual variations in direct oral anticoagulant (DOAC) plasma concentrations are observed for a given dose, leading to a risk of over‐ or under‐exposure and clinically significant adverse events. Physiologically‐based pharmacokinetic (...