Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells

• Main Authors: Mahmoud M. Mostafa (Author), Christopher F. Rider (Author), Suharsh Shah (Author), Suzanne L. Traves (Author), Paul M. K. Gordon (Author), Anna Miller-Larsson (Author), Richard Leigh (Author), Robert Newton (Author)
• Format: Book
• Published: BMC, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Glucocorticoids act on the glucocorticoid receptor (GR; NR3C1) to resolve inflammation and, as inhaled corticosteroids (ICS), are the cornerstone of treatment for asthma. However, reduced efficacy in severe disease or exacerbations indicates a need to improve ICS actions. Methods...