High-dose melphalan-based chemotherapy and autologous stem-cell transplantation for high-risk osteosarcoma in children: A single-institute experience and review of the literature

• Main Authors: Hideki Sakiyama (Author), Satoru Hamada (Author), Nobuyuki Hyakuna (Author), Takeshi Yagi (Author), Tokiko Oshiro (Author), Taichi Uehara (Author), Shinobu Kiyuna (Author), Jiro Miyamoto (Author), Takehiro Matsuda (Author), Takeshi Higa (Author), Koichi Nakanishi (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The prognosis of high-risk osteosarcoma, defined by the presence of chemo-resistance, metastatic disease at diagnosis, and relapse, remains poor. The efficacy of high-dose chemotherapy (HDC) and autologous stem-cell transplantation (ASCT) for high-risk osteosarcoma is still unclear. Meth...