Preparation of a Zirconium-89 Labeled Clickable DOTA Complex and Its Antibody Conjugate

• Main Authors: Falguni Basuli (Author), Olga Vasalatiy (Author), Jianfeng Shi (Author), Kelly C. Lane (Author), Freddy E. Escorcia (Author), Rolf E. Swenson (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Desferrioxamine B (DFO) is the clinical standard chelator for preparing zirconium-89 labeled antibodies. In the current study, the stabilities of a zirconium-89 labeled panitumumab (PAN; Vectibix^®) with three different chelators (DFO, DFO*, and DOTA) were compared. PAN is an a...