Sex-related differences of lipid metabolism induced by triptolide: The possible role of the LXRα/SREBP-1 signaling pathway

• Main Authors: Zhenzhou eJiang (Author), Xiao eHuang (Author), Shan eHuang (Author), Hongli eGuo (Author), Lu eWang (Author), Xiaojiaoyang eLi (Author), Xin eHuang (Author), Tao eWang (Author), Luyong eZhang (Author), Lixin eSun (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triptolide, a diterpenoid isolated from the plant Tripterygium Hook. f., exerts a unique bioactive spectrum of anti-inflammatory and anticancer activities. However, triptolide's clinical applications are limited due to its severe toxicities.Fatty liver toxicity occurs in response to triptolide,...