Identification and evaluation of antiviral activity of novel compounds targeting SARS-CoV-2 virus by enzymatic and antiviral assays, and computational analysis

• Main Authors: Ivana Nemčovičová (Author), Katarína Lopušná (Author), Iveta Štibrániová (Author), Fabio Benedetti (Author), Federico Berti (Author), Fulvia Felluga (Author), Sara Drioli (Author), Mattia Vidali (Author), Jaroslav Katrlík (Author), Lucia Pažitná (Author), Alena Holazová (Author), Jana Blahutová (Author), Simona Lenhartová (Author), Monika Sláviková (Author), Boris Klempa (Author), Miroslav Ondrejovič (Author), Daniela Chmelová (Author), Barbora Legerská (Author), Stanislav Miertuš (Author), Mária Klacsová (Author), Daniela Uhríková (Author), Lukáš Kerti (Author), Vladimír Frecer (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

AbstractThe viral genome of the SARS-CoV-2 coronavirus, the aetiologic agent of COVID-19, encodes structural, non-structural, and accessory proteins. Most of these components undergo rapid genetic variations, though to a lesser extent the essential viral proteases. Consequently, the protease and/or...