Novel <i>N</i>-Arylsulfonylindoles Targeted as Ligands of the 5-HT₆ Receptor. Insights on the Influence of C-5 Substitution on Ligand Affinity

• Main Authors: Loreto Arrieta-Rodríguez (Author), Daniela Espinoza-Rosales (Author), Gonzalo Vera (Author), Young Hwa Cho (Author), David Cabezas (Author), David Vásquez-Velásquez (Author), Jaime Mella-Raipán (Author), Carlos F. Lagos (Author), Gonzalo Recabarren-Gajardo (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new series of twenty-two C-5 substituted <i>N</i>-arylsulfonylindoles was prepared with the aim of exploring the influence of C-5 substitution on 5-HT₆ receptor affinity. Eleven compounds showed moderate to high affinity at the receptor (<i>K</i><s...