Allosteric inhibitor of SHP2 enhances macrophage endocytosis and bacteria elimination by increasing caveolae activation and protects against bacterial sepsis

• Main Authors: Tianliang Li (Author), Bing Xu (Author), Wenqian Li (Author), Xiaotao Cheng (Author), Wenjing Tantai (Author), Haiyan Zheng (Author), Liming Zhao (Author), Nan Li (Author), Chaofeng Han (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The uncontrolled bacterial infection-induced cytokine storm and sequential immunosuppression are commonly observed in septic patients, which indicates that the activation of phagocytic cells and the efficient and timely elimination of bacteria are crucial for combating bacterial infections. However,...