Connexin 43 impacts on mitochondrial potassium uptake

• Main Authors: Kerstin eBoengler (Author), Elvira eUngefug (Author), Gerd eHeusch (Author), Luc eLeybaert (Author), Rainer eSchulz (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In cardiomyocytes, connexin 43 (Cx43) forms gap junctions and unopposed hemichannels at the plasma membrane, but the protein is also present at the inner membrane of subsarcolemmal mitochondria. Both inhibition and genetic ablation of Cx43 reduce ADP-stimulated complex 1 respiration. Since mitochond...