Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy

• Main Authors: Cecile Lebon (Author), Heike Neubauer (Author), Marianne Berdugo (Author), Kimberley Delaunay (Author), Elke Markert (Author), Kolja Becker (Author), Katja S. Baum-Kroker (Author), Jürgen Prestle (Author), Holger Fuchs (Author), Remko A. Bakker (Author), Francine Behar-Cohen (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rho-associated kinase (ROCK) activation was shown to contribute to microvascular closure, retinal hypoxia, and to retinal pigment epithelium (RPE) barrier disruption in a rat model of diabetic retinopathy. Fasudil, a clinically approved ROCK inhibitor, improved retinal perfusion and reduced edema in...