The Ile191Val is a partial loss-of-function variant of the TAS1R2 sweet-taste receptor and is associated with reduced glucose excursions in humans

• Main Authors: Joan Serrano (Author), Jaroslava Seflova (Author), Jihye Park (Author), Marsha Pribadi (Author), Keisuke Sanematsu (Author), Noriatsu Shigemura (Author), Vanida Serna (Author), Fanchao Yi (Author), Andrea Mari (Author), Erik Procko (Author), Richard E. Pratley (Author), Seth L. Robia (Author), George A. Kyriazis (Author)
• Format: Book
• Published: Elsevier, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Sweet taste receptors (STR) are expressed in the gut and other extra-oral tissues, suggesting that STR-mediated nutrient sensing may contribute to human physiology beyond taste. A common variant (Ile191Val) in the TAS1R2 gene of STR is associated with nutritional and metabolic outcomes in...