Exploring the natural products chemical space through a molecular search to discover potential inhibitors that target the hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD)

• Main Authors: Abrar Mohammad Sayaf (Author), Saif Ullah Khalid (Author), Jawad Ahmed Hameed (Author), Abdulrahman Alshammari (Author), Abbas Khan (Author), Anwar Mohammad (Author), Saeed Alghamdi (Author), Dong-Qing Wei (Author), KarKheng Yeoh (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Hypoxia-inducible factor (HIF) prolyl hydroxylase domain (PHD) enzymes are major therapeutic targets of anemia and ischemic/hypoxia diseases. To overcome safety issues, liver failure, and problems associated with on-/off-targets, natural products due to their novel and unique structure...