Challenges with sirolimus experimental data to inform QSP model of post‐transplantation cyclophosphamide regimens

• Main Authors: Ezhilpavai Mohanan (Author), Guofang Shen (Author), Suping Ren (Author), Hsuan‐Hao Fan (Author), Kao Tang Ying Moua (Author), Aleksandra Karolak (Author), Russell C. Rockne (Author), Ryotaro Nakamura (Author), David A. Horne (Author), Christopher G. Kanakry (Author), Donald E. Mager (Author), Jeannine S. McCune (Author)
• Format: Bog
• Udgivet: Wiley, 2024-08-01T00:00:00Z.
• Fag: article
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Abstract Dose optimization of sirolimus may further improve outcomes in allogeneic hematopoietic cell transplant (HCT) patients receiving post‐transplantation cyclophosphamide (PTCy) to prevent graft‐versus‐host disease (GVHD). Sirolimus exposure-response association studies in HCT patients (i.e., t...