Oxidative stress‐induced dysregulation of excitation-contraction coupling contributes to muscle weakness

• Main Authors: Rizwan Qaisar (Author), Shylesh Bhaskaran (Author), Pavithra Premkumar (Author), Rojina Ranjit (Author), Kavithalakshmi Satara Natarajan (Author), Bumsoo Ahn (Author), Kaitlyn Riddle (Author), Dennis R. Claflin (Author), Arlan Richardson (Author), Susan V. Brooks (Author), Holly Van Remmen (Author)
• Format: Book
• Published: Wiley, 2018-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background We have previously shown that the deletion of the superoxide scavenger, CuZn superoxide dismutase, in mice (Sod1−/− mice) results in increased oxidative stress and an accelerated loss of skeletal muscle mass and force that mirror the changes seen in old control mice. The goal of...