Development of the optimal scheme for the synthesis of the dipeptide TSPO ligand, N-phenylpropionyl-L-tryptophanyl-L-leucine amide (GD-102), a potential anxiolytic drug

• Autor Principal: O. A. Deeva (Author)
• Formato: Libro
• Publicado: LLC "Publisher OKI", 2024-01-01T00:00:00Z.
• Subjects: article
• Acceso en liña: Connect to this object online.

Previously at the Zakusov Research Institute of Pharmacology the first dipeptide ligand TSPO, the compound N-phenylpropionyl-L-tryptophanyl-L-leucine amide (laboratory code GD-102), was designed and synthesized. The anxiolytic activity was detected for this compound at the doses 0.01-1.0 mg/kg intra...