Induction of mucosal immunity by pulmonary administration of a cell-targeting nanoparticle

• Main Authors: Tomoaki Kurosaki (Author), Yuki Katafuchi (Author), Junya Hashizume (Author), Hitomi Harasawa (Author), Hiroo Nakagawa (Author), Mikiro Nakashima (Author), Tadahiro Nakamura (Author), Chikamasa Yamashita (Author), Hitoshi Sasaki (Author), Yukinobu Kodama (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously found that a nanoparticle constructed with an antigen, benzalkonium chloride (BK) and γ-polyglutamic acid (γ-PGA) showed high Th1 and Th2-type immune induction after subcutaneous administration. For prophylaxis of respiratory infections, however, mucosal immunity should be induced. In...