Impaired APP activity and altered Tau splicing in embryonic stem cell-derived astrocytes obtained from an APPsw transgenic minipig

• Main Authors: Vanessa J. Hall (Author), Maiken M. Lindblad (Author), Jannik E. Jakobsen (Author), Anders Gunnarsson (Author), Mette Schmidt (Author), Mikkel A. Rasmussen (Author), Daniela Volke (Author), Thole Zuchner (Author), Poul Hyttel (Author)
• Format: Book
• Published: The Company of Biologists, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Animal models of familial juvenile onset of Alzheimer's disease (AD) often fail to produce diverse pathological features of the disease by modification of single gene mutations that are responsible for the disease. They can hence be poor models for testing and development of novel drugs. Here,...