Snrpb is required in murine neural crest cells for proper splicing and craniofacial morphogenesis

• Main Authors: Sabrina Shameen Alam (Author), Shruti Kumar (Author), Marie-Claude Beauchamp (Author), Eric Bareke (Author), Alexia Boucher (Author), Nadine Nzirorera (Author), Yanchen Dong (Author), Reinnier Padilla (Author), Si Jing Zhang (Author), Jacek Majewski (Author), Loydie A. Jerome-Majewska (Author)
• Format: Book
• Published: The Company of Biologists, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Heterozygous mutations in SNRPB, an essential core component of the five small ribonucleoprotein particles of the spliceosome, are responsible for cerebrocostomandibular syndrome (CCMS). We show that Snrpb heterozygous mouse embryos arrest shortly after implantation. Additionally, heterozygous delet...