A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes

• Những tác giả chính: Ahrim Youn (Tác giả), Kyung In Kim (Tác giả), Raul Rabadan (Tác giả), Benjamin Tycko (Tác giả), Yufeng Shen (Tác giả), Shuang Wang (Tác giả)
• Định dạng: Sách
• Được phát hành: BMC, 2018-11-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Abstract Background Recent large-scale cancer sequencing studies have discovered many novel cancer driver genes (CDGs) in human cancers. Some studies also suggest that CDG mutations contribute to cancer-associated epigenomic and transcriptomic alterations across many cancer types. Here we aim to imp...