Methylprednisolone Treatment in Brain Death-Induced Lung Inflammation-A Dose Comparative Study in Rats

• Main Authors: Judith E. Van Zanden (Author), Nils A. 'T Hart (Author), Petra J. Ottens (Author), Bo Liu (Author), Rolando A. Rebolledo (Author), Michiel E. Erasmus (Author), Henri G. D. Leuvenink (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The process of brain death (BD) leads to a pro-inflammatory state of the donor lung, which deteriorates its quality. In an attempt to preserve lung quality, methylprednisolone is widely recommended in donor lung management. However, clinical treatment doses vary and the dose-effect relat...