HO-1 Limits the Efficacy of Vemurafenib/PLX4032 in BRAF^V600E Mutated Melanoma Cells Adapted to Physiological Normoxia or Hypoxia

• Main Authors: Anna Lisa Furfaro (Author), Giulia Loi (Author), Caterina Ivaldo (Author), Mario Passalacqua (Author), Gabriella Pietra (Author), Giovanni Enrico Mann (Author), Mariapaola Nitti (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Induction of heme oxygenase 1 (HO-1) favors immune-escape in BRAF^V600 melanoma cells treated with Vemurafenib/PLX4032 under standard cell culture conditions. However, the oxygen tension under standard culture conditions (~18 kPa O₂) is significantly high...