Targeting stroma and tumor, silencing galectin 1 treats orthotopic mouse hepatocellular carcinoma

• Main Authors: Tahereh Setayesh (Author), Ying Hu (Author), Farzam Vaziri (Author), Xin Chen (Author), Jinping Lai (Author), Dongguang Wei (Author), Yu-Jui Yvonne Wan (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study examines inhibiting galectin 1 (Gal1) as a treatment option for hepatocellular carcinoma (HCC). Gal1 has immunosuppressive and cancer-promoting roles. Our data showed that Gal1 was highly expressed in human and mouse HCC. The levels of Gal1 positively correlated with the stages of human H...