Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers

• Main Authors: Chao Wang (Author), Yuelin Li (Author), Zi Liu (Author), Zeyu Wang (Author), Zihan Liu (Author), Shuai Man (Author), Yujing Zhang (Author), Kai Bao (Author), Yingliang Wu (Author), Qi Guan (Author), Daiying Zuo (Author), Weige Zhang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as microtubule destabilizers were designed, synthesised and evaluated for anticancer activity. Based on bioisosterism, we introduced the tetrazole moiety containing the hydrogen-bond acceptors as B-ring of XRP44X analogues. The key inte...