Design, synthesis and biological evaluation of 1-Aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as novel microtubule destabilizers

• প্রধান লেখক: Chao Wang (লেখক), Yuelin Li (লেখক), Zi Liu (লেখক), Zeyu Wang (লেখক), Zihan Liu (লেখক), Shuai Man (লেখক), Yujing Zhang (লেখক), Kai Bao (লেখক), Yingliang Wu (লেখক), Qi Guan (লেখক), Daiying Zuo (লেখক), Weige Zhang (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

A series of 1-aryl-5-(4-arylpiperazine-1-carbonyl)-1H-tetrazols as microtubule destabilizers were designed, synthesised and evaluated for anticancer activity. Based on bioisosterism, we introduced the tetrazole moiety containing the hydrogen-bond acceptors as B-ring of XRP44X analogues. The key inte...