Ca2+/Calmodulin-Dependent Protein Kinase II and Androgen Signaling Pathways Modulate MEF2 Activity in Testosterone-Induced Cardiac Myocyte Hypertrophy

• Main Authors: Javier Duran (Author), Daniel Lagos (Author), Mario Pavez (Author), Mayarling F. Troncoso (Author), Sebastián Ramos (Author), Genaro Barrientos (Author), Cristian Ibarra (Author), Sergio Lavandero (Author), Manuel Estrada (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Testosterone is known to induce cardiac hypertrophy through androgen receptor (AR)-dependent and -independent pathways, but the molecular underpinnings of the androgen action remain poorly understood. Previous work has shown that Ca2+/calmodulin-dependent protein kinase II (CaMKII) and myocyte-enhan...