Isonitrile-Based Multicomponent Synthesis of β-Amino Boronic Acids as β-Lactamase Inhibitors

• Ngā kaituhi matua: Emanuele Bassini (Author), Stefano Gazzotti (Author), Filomena Sannio (Author), Leonardo Lo Presti (Author), Jacopo Sgrignani (Author), Jean-Denis Docquier (Author), Giovanni Grazioso (Author), Alessandra Silvani (Author)
• Hōputu: Pukapuka
• I whakaputaina: MDPI AG, 2020-05-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

The application of various isonitrile-based multicomponent reactions to protected (2-oxoethyl)boronic acid (as the carbonyl component) is described. The Ugi reaction, both in the four components and in the four centers-three components versions, and the van Leusen reaction, proved effective at provi...