Epigallocatechin-3-Gallate Suppresses BMP-6-Mediated SMAD1/5/8 Transactivation of Hepcidin Gene by Inducing SMILE in Hepatocytes

• Asıl Yazarlar: Yu-Ji Kim (Yazar), Woo-Ram Park (Yazar), Byungyoon Choi (Yazar), Hueng-Sik Choi (Yazar), Don-Kyu Kim (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2021-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Hepcidin, a major regulator of systemic iron homeostasis, is mainly induced in hepatocytes by activating bone morphogenetic protein 6 (BMP-6) signaling in response to changes in the iron status. Small heterodimer partner-interacting leucine zipper protein (SMILE), a polyphenol-inducible transcriptio...